This difference could provide some useful insights into the the origin of overlapping genes.
In the Background section, the authors discuss the mutational origins of overlaps and the interplay of neutral or adaptive processes in their evolution.
Combining such sub area maps with maps of spatial overlap of digits will allow confirmation of whether the degree of spatial overlap varies across sub areas 3a, 3b, 1, and 2. A potentially complicating factor for the interpretation of the origin of spatial overlap is the difference in the distribution of large draining veins across sulci and gyri.
Similar to the center of origin, the region of overlap hypothesis predicts that the most diverse (but not oldest) populations will be centered in the CT, however in this case the high diversity is the result of the overlap of divergent lineages from peripheral regions.
Dahary et al. [ 11] place the origin of most vertebrate overlaps much earlier.
Based on anatomical specimens and recently published work on the radiographic anatomy of the equine stifle soft tissue attachments [ 14], the area where the caudal half of the origin of the LCL overlaps with the cranial half of the origin of MCL was used to define a lateral view of the stifle.
In this paper we explore the selective implications of statistical regularities in phase diversity, we explicitly introduce statistical, null models against which we compare the data, and we identify the ongoing legacy of mutational origins in established patterns of overlap in a large set of prokaryotic genes.
Also, decadal and shorter signals originating in the Earth's core have been recently studied (Gillet et al. 2010; Silva et al. 2012; Holme and de Viron 2013; Cox et al. 2016); however, additional effort is needed to decide on the origin and degree of overlapping.
Therefore lack of strong overlaps conservation between even closely related species may result from the origin of a new, lineage specific overlap as well as from the loss of overlaps in many lineages.
For example, Shintani et al. [ 28] studied the evolutionary origin of TCP1 and ACAT2 that overlap in their 3' UTR on different strands and suggested that the overlap arose during the transitions from therapsid reptiles to mammals and has been retained for >200 million years.
