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The origin of functional innovation is among the key questions in biology.
Interestingly, the evolutionary origin of functional AS is likely related to mis-splicing (splicing errors).
Therefore, the widespread production of multiple splice forms could be a main requirement for the origin of functional AS.
We have addressed the origin of functional domains in the entire human proteome by tracing them hierarchically along the Homo sapiens lineage.
The difference in dendritic location for male and female aSP-f neurons provides a simple circuit hypothesis for the origin of functional differences between these neurons.
Furthermore, among these 30 expressed relics, we found one brachypodium relic, two rice relics and two sorghum relics may function as ceRNAs, indicating a potential contribution of unitary gene loss to the origin of functional non-coding RNAs.
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The central nervous origins of functional parasympathetic innervation of cardiac ventricles remain controversial.
To our knowledge, this is the first report on the origins of functional domains in the entire human proteome carried out by subtractive searching along the evolutionary lineage of Homo sapiens.
Moreover, some differences among the two age groups are prominent, such as that the early-middle-aged consumers show a great interest in knowing the origin of the functional product; while the young adults emphasize on functional foods' convenience and (low) price.
The results of theoretical investigations presented here will shed light on the origin of the functional properties of this relatively new family of materials.
In addition, the comprehensive hemoglobin contrasts of fc-DOT enable innovative studies of the biophysical origin of the functional connectivity signal.
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