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Infections were categorized by anatomical sites as well as by their most probable origin of acquisition (community- versus healthcare-setting).
Data of the 114 patients were categorized according to the probable healthcare-associated or community origin of acquisition of ESBL-producing Enterobacteriaceae.
Of the 386 S. flexneri and S. sonnei isolates, 74.9% (n = 289) were associated with international travel; 12.7% (n = 49) associated with domestic exposure within North America; 12.4% (n = 48) unknown travel history or origin of acquisition.
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PCR failed to give any positive results, confirming the absence of an IncA/C-type plasmid and also ruling out the hypothesis of IncA/C2-type plasmid co-integration at the origin of blaVEB-1 acquinition in P. aeruginosa.
Interestingly, two of these predicted amino acids, Thr229 and Arg320, had been previously identified for their role in fosmidomycin/substrate binding and in dimerization, respectively [ 26], suggesting that functional shifts in a limited number of amino acid positions could be at the origin of the acquisition of DXR-II biochemical activity.
The origin and mode of acquisition of the OsRpl6-2 5'-UTR is unknown.
Their nearest structural protein neighbors are found in prophages that are maintained as linear plasmid-like entities in γ-proteobacterial hosts (Halomonas, Vibrio), which suggests a different evolutionary origin and route of acquisition compared with the tailocins of the P. aeruginosa and P. putida complexes.
Examination of additional wild strains from ongoing resequencing efforts (S. Baker, K. McCluskey, I. Grigoriev, J. Stajich, and unpublished data) provided a better understanding of the origins and timing of acquisition of this newly described selfish genetic element.
Isolates that belonged to European clone I had diverse genetic structures at the origin of blaOXA-23 acquisition.
The origin of the malaria acquisition is not known for every reported malaria case and may underestimate the true number of malaria cases from West Africa.
Despite some functional ambiguity, judging from the lines of evidence presented here, our results constitute a plausible explanation for the origin and acquisition of the 5'-noncoding region.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com