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In order to fix this problem, we should expand our area of calculation beyond borders, including also all opportunities inside the surrounding buffer area of our study area and calculate the impedances between each origin in our study region and these opportunities as destination.
Since CK19CreERT labels <1% of acinar cells [17], we would expect to see a much lower frequency (∼1/50th the number) of lesions than those seen from elastase-driven activation of KrasG12D if acinar cells were the cell of origin in our study.
Thus, no impression of tissue of origin in our study is not likely due to the lack of the resolution of the nucleosome position map.
Compared to findings from several studies based on hospital presentations for self-harm in China, which showed a mean age around 31 33 years [ 31- 33], people of Chinese origin in our study appeared to be somewhat younger (mean age 28 years) and overrepresented by students (44%).
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Additionally, the weakly pathogenic strains (biotype 2 4, serotype O: 3 or O: 9 strains) included wild strains from China and reference strains not from China showed no differences even if they were isolated from different origins in our study.
The association between underprescribing and a nursing home origin found in our study is curious.
Distinct roles for CDK4 and CDK6 in cells of embryonic origin are suggested in our study, by differing metabolism of CDK4- and CDK6-containing complexes.
The proportion of patients with detection of a plausible pathogen differed among the various origins of infection in our study.
The clinical characteristics of people of Chinese origin who self-harmed in our study were generally similar to findings from China.
Furthermore, in contrast to Indians and Pakistanis, who experienced much higher rates than their countries of origin, rates among Bangladeshis in our study were very similar to those reported in Bangladesh [ 2].
The apparent discrepancy of identical mutations showing different multimerization abilities can be explained by the different origin of the proteins in our study and that of Korhonen et al. (29).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com