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We observed three distinct patterns of duplication events for B3 genes according to their duplication origin: genes that were duplicated and inserted in different chromosomes, genes that were duplicated and inserted in the same chromosome and genes that were duplicated in tandem.
However, the avian origin genes of human H3N2 (HA and PB1) extend from the avian cluster.
This indicates that the origin genes were all clustered and very close to our putative origin.
Ancient origin genes with an ortholog in Drosophila melanogaster are marked with a red asterisk.
We used these so-called origin genes to assess POML as follows.
The results confirm that the replication origin is frequently near one or more of the set of "origin genes".
Similar(53)
Currently, H1 and H3 subtypes circulate in pigs globally associated with different combinations of N1 and N2 subtypes; however, the origin, gene constellation, and antigenic makeup of IAV vary greatly on different continents.
Number of "origin gene" pairs found in any given chromosome, as defined in the text.
Additionally, a fungal origin gene with function of carotenoid metabolism was found in the aphid genome [ 8].
When multiple origin gene pairs are found near POML it indicates that the gene pairs are close together on the chromosome.
Although most functional gene transfers from organelles to the nucleus occurred shortly after their endosymbiotic origin, gene transfer is an ongoing process [ 25].
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