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They were of Ashkenazi Jewish origin, defined as having all 4 grandparents born in Northern or Eastern Europe.
Inclusion criteria were age ≥18 years, Caucasian origin (defined as 4 grandparents born in Europe, or in the Maghreb), gestational age ≥20 weeks, and PE defined according to the definition of the American College of Obstetricians and Gynecologists (ACOG) [20].
Indeed, the re-plotting of our data with the time origin defined as light offset instead of light onset, revealed a clear alignment of gene patterns in the liver (Figure 2A).
These motifs include the canonical 'core origin,' defined as the minimal DNA requirement for the initiation of replication, binding the terminal protein-DNA polymerase complex [38], and several host transcription factor binding sequences which are required for efficient adenovirus replication [39], [40].
Inclusion criteria were: (i) a histopathological diagnosis of any type of breast cancer, and (ii) self-reported Sardinian origin, defined as both biological parents and all four biological grandparents born on the island.
The following inclusion criteria were applied: 1) provided written informed consent; 2) was aged 35 75 years; 3) was willing to take part in the examination and donate blood samples; and 4) was of Caucasian origin, defined as having both parents and grandparents born in a restricted list of countries (available from the authors).
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According to a 2014 Gallup poll, about 42% of Americans accept a Creationist view of human origins, defined as those claiming that "God created humans in their present form", and only about 19% accept an explanation of evolution that does not involve divine influence.
The first one is the total emigration rates for each origin country defined as the total stock of migrants abroad over the total working population (total labor force).
A predicted origin was defined as 'real' if it was located within 5 Kb to some known origin (confirmed and likely origins in OriDB [ 35]).
Origin is defined as "the heritage, nationality group, lineage or country of the person or the person's parents or ancestors before their arrival in the United States".
Ethnic origin was defined as Nordic Caucasian when the pregnant woman originated from Northern Europe.
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