That modifications resulted in a new, corrected, data set of 68 sequences of likely Native American origin, and, in a third data set with only the 9 sequences which have been misincorporated in the original data set of 77 sequences analyzed by Kitchen et al. [20].
Now, however, with the advent of high-resolution origin data sets with origin-firing times annotated (Feng et al. 2006; Nieduszynski et al. 2007; McCune et al. 2008) it is possible to test if the casually observed colocalization of origins and breakpoints is significant.
Depending on the shape of each origin's firing time distribution, the changes in I t) at the start and the end of S phase may not be exactly as portrayed since initiations can occur before or after the assigned timepoint of the origin in the data set.
Because no systematic clustering of populations by data set of origin is observed for any of the source data sets, our MDS analyses support the correct alignment of genotypes in the individual data sets during construction of the combined human data set.
As figure 1 shows, all individuals clustered according to the inversion status and continental origin regardless of the data set used.
By using Equation (2) and the S. pombe genome size Ltotal = 14 Mb, we calculated the rate of replication origin firing, I t), for each data set.
Genotype data from only 50 random SNPs was sufficient to predict ancestral continent of origin in our primary test data set with an average accuracy of 95%.
Genotype data from 50 random SNPs is sufficient to predict ancestral continent of origin in our primary test data set with an average accuracy of 95%.
