The "tales" of Genesis, it flatly stated, were a mix of "myth, legend, distant memory and search for origins, bound together by the strands of a central theological concept".
One prediction of this idea is that origins bound by ORC but passively replicated by a fork emanating from a nearby origin would experience fork pausing and thus should appear to be correlated with breakpoints.
As origins bind to ORC ubiquitously, helicase loading and its activation are regulated in the S phase.
Dormant origins bind a pre-RC and are licensed in G1 [ 4], and if given enough time they are competent to initiate replication [ 43, 44].
10.7554/eLife.04251.009 Figure 5. Nup98 FG domains of diverse evolutionary origin bind human Importin β. (A ) This study analyses ten Nup98 FG domains from nine species.
Previously, it was shown that LysM domains from plant origin bind to NAG derivatives (Ohnuma et al. 2008; Petutschnig et al. 2010).
It has been argued that the T-cell response to an arthritogenic peptide(s) of endogenous origin and bound by HLA-B27 molecules might be the cause of spondyloarthropathies.
Eukaryotic chromosomes possess multiple origins, each bound by the six-subunit origin recognition complex (ORC; composed of Orcs 1 6), which recruits the replicative helicase (the MCM complex) via interactions with Cdc6 and Cdt1 (Duncker et al., 2009; Bochman and Schwacha, 2009).
The level of chromatin-associated MCM protein that we obtained corresponds to roughly 300 origins being bound in this manner, which is the range of the number of origins that are reported to potentially fire per cell per cell cycle according to various global origin characterization studies [ 65, 90- 92].
Association of Cdc45 with early-firing origins peaked at 30 min after release from G1 arrest (Fig 1B E), whereas late-firing origins were bound by Cdc45 at 40 70 min after the release (Fig 1F H), which is in good agreement with previously reported firing times of these origins [ 13, 14, 15, 23].
