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There is currently no consensus on the understanding of the lineage origin and developmental bias of MSCs.
A more complete understanding of the origin and developmental program of coronary vessels would contribute important information to the field of cardiovascular regenerative medicine.
It is known that miRNA expression is highly specific for the tissue of origin and developmental stage (Landgraf et al, 2007; Niwa and Slack, 2007).
FISH analysis and the sequences of three BAC clones described in this study provide a good explanation on the origin and developmental procedures involved in the evolution of IGS-homologous satellite repeats because they contain both the original form and early stages of the variants in a genome.
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Defining the origins and developmental pathways of tissue-resident macrophages should help refine our understanding of the role of these cells in various disease settings and enable the design of novel macrophage-targeted therapies.
By studying the distinct origins and developmental processes of the ureteric bud, which contains epithelial kidney progenitors that undergo branching morphogenesis and thereby plays a central role in orchestrating organ geometry, and neighboring mesenchymal nephron progenitors, we established a protocol for differential induction of each lineage from mouse and human PSCs.
Despite the relevance to human health and reproductive technologies, the origins and developmental dynamics of mammalian sexual dimorphism have not been characterized in detail.
Stebbins discusses the origins, genetics and developmental biology of the angiosperms.
For instance, cells in cranial and appendicular skeletal tissues have different embryologic origins, and so developmental constraints may limit the molecular fingerprint of a skeletal cell that appears in both regions.
Most importantly, finding the connection between microscopic and macroscopic dynamics and the unifying laws are crucial for understanding the origins of evolutionary and developmental robustness of living systems to diverse environmental attacks.
One problem in discussing the differences in arrangement of muscles between the various vertebrate groups is in deciding which muscles in each species are homologous that is, which have the same evolutionary and developmental origin.
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