P-values for PWM scores were computed with the standard method [50], which was extended to consider searches over both sequence orientations and to adopt a dinucleotide model for random sequences as described in the following.
The structural plasticity of α-actinin-2 has implications for not only its regulation but also for actin filament binding both in muscle and nonmuscle isoforms, where actin filaments are randomly oriented, requiring ABDs to adopt variable orientations.
Consequently, to the extent that the cyclic hemiacetals open to unmask the corresponding aldehydes 6 and 7, the latter are anticipated to adopt orientations similar to those of the respective cyclic hemiacetals 8 and 10, from which they are derived.
The Human Rights Campaign has given him a score of 0 for voting against legislation that would ban discrimination in the workplace based on sexual orientation and for refusing to adopt a written policy for his own office pledging not to discriminate on the basis of sexual orientation.
These lobes were previously thought to adopt various orientations relative to each other to deliver ubiquitin to sites on different target proteins (including to multiple lysines on a single target protein).
Thus, it seems to be a crucial step for melittin action which enables the peptide molecules to adopt proper orientation either for pore formation or disruption of the membrane.
The likely presence of an intramolecular hydrogen bond between G3 HN21 and R2 O31/O32, which requires this group to adopt this orientation, is considered to be the cause of this.
In isolation, the structures would be free to adopt any orientation in a plane perpendicular to a single magnetic field axis.
Whilst α2 is obliged by convention to be parallel with the b-axis, α1 and α3 are free to adopt any orientation they wish in the ac plane, whilst remaining orthogonal to one another; we find that α3 is tilted by just over 20° from the c-axis.
Yet cholesterol can transform this inactive conformation by forcing the galactose ring to adopt a parallel orientation compatible with the stacking of Y10.
