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The phosphoanhydride region of the ligation donor changes its orientation to interact with the 3'-OH RNA with more optimal geometry for strand joining [ 4].
The FKBP12 receptor positions rapamycin in the optimal orientation to interact with the TOR proteins and also supplies structural determinants that contribute to the affinity and specificity of this interaction.
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Self-construal orientations have shown to interact with nation-level cultural orientation to influence entrepreneurship intentions (Siu & Lo, 2013), and further research should explore the contribution of those in women entrepreneurship.
First, there are geometrical constraints since the molecules bound to the scaffold protein need to have the right orientation in order to interact.
Numerous hydrophobic contacts between BPA and PXR further stabilize ligand binding and indirectly promote contact with the AF-2 region, thus facilitating proper orientation of αAF to interact with coactivators.
Our in silico studies identified that, in RA-PI3Kγ, these Glu residues are present towards the β-sheet extension and their orientation does not allow them to interact adequately with the CNGA1 in a manner that would facilitate modulation of its activity.
► The ability to interact using different orientations of the reporter dipole on actin.
Thus, the ability to interact using different orientations of the reporter dipole on actin was an important feature of the single actomyosin molecules in skeletal muscle myofibrils.
The most often seen interaction is to Asp235, and most compounds bind with a specific orientation that is defined by their ability to interact with this residue.
This substrate mimics a DNA break, the physiological substrate for AddAB, with the hairpin loop forcing AddAB to interact in the desired orientation.
Such an orientation would allow the lipid moiety of LTA to interact with hydrophobic surfaces of host cells and tissues.
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