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It is believed that DNA binding by Fe·BLM must precede cleavage, limiting cleavage to a subset of those DNA and RNA sites bound effectively by Fe·BLM, and having the bound Fe·BLM DNA complex in an orientation that permits abstraction of a H atom from C-4′ of (deoxy)ribose in the rate-limiting chemical step.
In this assay, one expects ∼50% of the binding events to occur in the correct orientation that permits recognition of HS1/HS2, and the remaining 50% to occur with the duplex DNA in the incorrect orientation, which may not lead to recognition of HS1/HS2.
Similar(58)
We designed an in vitro and ex vivo experimental model that permits the controlled orientation of thinned renal parenchyma and background activity during γ camera detection.
The mounting describes the orientation of the physical bearings and structure that permits a telescope to be pointed at a celestial object for viewing.
We introduce a novel scanning scheme that permits to measure any vessel orientation around the ONH under optimal conditions.
It harbors a particular combination of cleavage sites that permits cloning of a nucleic acid in defined orientation and controlled labeling of only the desired fragments with fluorescent dyes (Figs. 1, 2, 3).
I'm optimistic that Congress and the Administration, without resorting to yet another study, can throw out the single remaining law that permits, indeed demands the firing of someone because of his or her sexual orientation.
Excerpt: A law that permits compassion also permits revenge.
"Although much research has examined the possible genetic, hormonal, developmental, social and cultural influences on sexual orientation, no findings have emerged that permit scientists to conclude that sexual orientation is determined by any particular factor or factors," the APA says.
There are combinations of target and distractor orientations that do not permit parallel search (Wolfe, 1994).
He said the Bulls operated a policy directed towards sexual practice not sexual orientation and said they believed that permitting unmarried people - whether heterosexual or homosexual - to share a double bed involved them in "promoting a sin".
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CEO of Professional Science Editing for Scientists @ prosciediting.com