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This model system therefore provides a means for the experimental determination of the energetic contribution of a variety of interactions to helix orientation specificity.
In addition, well-behaved, model antiparallel coiled coils have been designed and used for the reassembly of protein fragments and for the study of the energetic contributions of various interactions to helix orientation specificity.
In this model, both the orientation specificity and the organization of receptive fields are determined by the geometry of cortical columns.
Analagous with the gamma band explanation we would attribute these subtle multivariate differences in the evoked response (mean field) to different populations of contributing neurons (with different optimal orientation specificity).
Although the bipartite motif-module showed no orientation specificity to 5' or 3' positioning in general, the GRE-AuxRE module seemed to be preferred compared to the AuxRE-GRE module constellation.
The differences in orientation specificity, and the fact that hysteresis and adaptation display markedly different time constants (Kanai and Verstraten 2005), further speak for a dissociation of their underlying mechanisms.
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Indeed, Hubel and Wiesel [37] demonstrated that neurons having similar orientation specificities aligned at right angle to the surface of the visual cortex.
The transposon inserts in a region-specific and orientation-specific manner within the repeat in the absence of its usual target specificity proteins TnsD or TnsE, suggesting that structures formed by the repeat somehow replace functions of those specificity factors.
Nevertheless, the orientation and contrast specificity of the detection [6] and instructed orienting [7] effects seen in neurotypical adults resembles closely the exogenous orienting responses seen in neurotypical infants [1].
However, only the tracts in vab-10 and CBG15813 could be considered conserved when the facts such as tract orientation and position specificity were taken into account (Table 2).
Based on the structure of GTF-SI and amino acid comparison of GTF-SI, GTF-I and GTF-S, Asp593 in GTF-SI appeared to be the most critical point for acceptor sugar orientation, influencing the transglycosylation specificity of GSases, that is, whether they produced insoluble glucan with α(1 3) glycosidic linkages or soluble glucan with α(1 6) linkages.
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