Even if XYY aneuploid males do not exhibit 2+1 pairing, it is useful to model biases in pairing, co-orientation, segregation, and recovery of sex chromosomes that vary in rDNA copy number.
The mixes were analyzed with respect to the number of contact points between aggregates, particles orientation and segregation potential.
Comparison of orientation of segregation distortion and additive effect of flowering time QTL on 10 chromosomes.
Meiotic crossovers (COs) are required for the establishment of cohesin-mediated inter-homolog interactions, which are in most organisms indispensible for the bipolar orientation and segregation of recombined chromosomes of maternal and paternal origin [10,11].
Polo-like kinase 1 (Plk1), Aurora A and Aurora B are three additional protein kinases that control a subset of critical mitotic events, including centrosome maturation and separation, chromosome orientation and segregation (Nigg, 2001).
We found a set of 40 commonly overexpressed genes at the HLA (Table 3), which included molecules that are known to be involved in the regulation of centrosome duplication, chromosome orientation, and segregation process in cells such as: AURKA, TPX2, CSE-1, MCM8 or SMC4 (Adams et al, 2001).
These data suggest that α and β need to be tightly regulated for efficient chromosome bi-orientation and segregation accuracy.
Gay et al. proposed a stochastic model of kinetochore microtubule attachments in fission yeast mitosis, which reproduced correct chromosome bi-orientation and segregation in simulations [ 19].
In meiosis, homologous chromosomes must recognize one another and recombine, forming physical links called crossovers (COs) that enable their bi-orientation and segregation in meiosis I (Zickler and Kleckner, 1999).
Regardless, with three chromosomes moving to two poles, preferential co-orientation and segregation in XYY aneuploid males may reveal subtle quantitative effects of rDNA intergenic spacer sequences as pairing sites.
This heterogeneity was discussed based on the effects of the grain orientation and the segregation of alloying elements.
