Unexpectedly, Ark1 is also necessary for the faithful mono-orientation of sister chromatids in meiosis-I, even though the canonical mono-orientation pathway, which depends on Moa1 and Rec8, seems intact.
However, notably different from budding yeast (Monje-Casas et al, 2007), we describe that fission yeast Aurora is required for the monopolar attachment of sister chromatids in meiosis-I, and acts in a different pathway from the Moa1/Rec8 mono-orientation pathway that has been defined.
One of the key questions remaining is how during the infection course the initial Th1-orientation switches to a rather Th2-oriented pathway.
The oil filling orientation and pathways are traced using molecular indicators related to alkyldibenzothiophenes and benzo[b]naphthothiophenes. The oil charging orientation is from south to north generally.
Open image in new window Fig. 9 Isopleth map of 4-/1-MDBT of the Ordovician oils showing the oil migration orientation and pathways in the Tuoputai region of the Tarim Basin, NW China.
Altogether, in vitro experiments with Netrin-1 in collagen matrix confirm the in/ex vivo observations: the orientation of axon pathway was not affected in TTL−/− neurons.
These in vivo data well-recapitulate the conclusion that Rbpj-mediated uterine functions include both Notch pathway-independent mechanism that governs embryonic-uterine orientation and Notch pathway-dependent mechanism that regulates decidual remodeling.
The ratio of [2,1]BNT/([2,1]BNT + [1,2]BNT) can be applied as a tracer for oil filling orientation and migration pathways (Li et al. 2014a).
The results suggest that these parameters can be used as an effective tracing indicator for oil filling orientation and migration pathways.
Probabilistic multi-fibre tractography applied to diffusion MRI data acquired at 3T may be better able to cope with crossing and kissing fibres than deterministic models because it allows many more possible local pathway orientations for each DTI sample point.
Later, biophysical a priori models, i.e., computer models that enable the in silico mimicking of in vivo conditions by using pre-programmed settings relating to physical properties, e.g., conduction velocity, fiber orientation, anisotropy, activation pathways, were introduced to compensate for the limited BSP data actually recorded [ 11].
