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Compared to static state, characterized by random orientation of cells, HUVEC progressively elongated and oriented in the direction of flow upon increasing shear hemodynamic forces (Fig. 1D,E).
Abnormal orientation of cells in the heart wall is a clue to arrhythmias, which can be fatal.
Planar cell polarity (PCP) refers to the collective orientation of cells within the epithelial plane.
Planar cell polarity (PCP) is manifested as the coordinated, polarized orientation of cells within epithelial sheets, or as directional cell migration and intercalation during convergent extension.
Restitution of the natural organization and orientation of cells is imperative for the construction of functional tissue scaffolds.
In some parts of native tissues, the orientation of cells and/or extracellular matrixes is well organized.
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The factors that control the orientation of cell division planes in meristems are largely unknown.
Owing to their immobility, plant cells determine body architecture through the orientation of cell division and cell expansion.
The researchers believe regulating orientation of cell divisions may have been an ancient function of the pathway, which aided the transition to land.
Miniature motion sensors are everywhere these days, detecting the orientation of cell phones, deploying air bags in cars and measuring stresses in buildings and mechanical systems.
To explore the signals from cell-matrix interactions that control orientation of cell polarity, we have used three-dimensional culture systems in which Madin-Darby canine kidney (MDCK) cells form polarized, lumen-containing structures.
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