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This orientation does not allow for H-bonding interactions with Q111 and T797, residues identified by mutagenesis studies to be critical for ouabain's inhibition of Na+/K+ ATPase.
A cardiac glycoside analog may have a higher binding energy to Na+/K+ ATPase, but if its orientation does not allow for effective blocking of the ion permeation path, binding of that analog may not result in efficient inhibition.
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However the static optical configuration used for previous studies does not allow for measuring every vessel orientation and thus any vessel of the retina.
American diplomacy does not allow for it.
Their setup, however, does not allow for unequally sized clusters.
Furthermore, it does not allow for real-time detection.
Consequently, it does not allow for individual-specific characteristics.
Of course, our methodology does not allow for national representativeness.
This does not allow for any more complex statistical analysis.
Football does not allow for that.
The short loop linking the two domains does not allow for large flexibility, providing a solid anchor point for the first YscD periplasmic domain at the membrane surface, and forcing a preferential perpendicular orientation to the IM.
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