Immunolabelling using antibodies directed to different phosphorylation sites on the Cx43 molecule suggests that dephosphorylated Cx43 is associated with the laterally distributed gap junction label, while those gap junctions that remain in the classic, polar intercalated disc orientation contain phosphorylated Cx43.
DOI: http://dx.doi.org/10.7554/eLife.02893.016 To determine whether Ft-Ds signaling regulates MT orientation in wing discs, and to determine whether it is instructive or merely necessary, we studied the boundaries of ft clones.
The thermal analysis of the receiver is carried out for various geometrical parameters such as angle, orientation, height of the disc (H) and distance between the discs (w) and for different heat flux conditions.
The change in the disc's orientation relative to the condyle moves its load-bearing zone from the biconcave articular portion to the vascularized posterior band, which has been shown to lead to osteoarthritis and subsequent condylar and mandibular deficiencies [25 27].
In contrast, from early third instar stage onward, the axis of cell division shows an oblique to orthogonal orientation relative to the disc surface.
However, recent tensile and shear evaluations have reported a higher stiffness of the tissue in the anteroposterior direction than in the mediolateral direction, corresponding to an anisotropic fiber orientation comparable to the TMJ disc.
Instead, they attached on both sides to the disc epithelium, adopting orientations perpendicular to the proximal-distal axis.
A flat edge was made on some of the discs to ease orientation and registration during imaging and analysis.
Instead, spindle orientation requires the lateral factor Discs large (Dlg), a function that is separable from its role in epithelial polarity.
The numerical approach is validated using uniform flow past a stationary circular cylinder, sedimentation of circular discs, and particle motion (orientation and translation) in unidirectional flows.
