Exact(3)
Any language, memory, or orientation abnormalities should also be noted.
Taken together, these findings suggest that inhibition of CRMP2 phosphorylation at Thr514 in Gsk3-deleted neurons may partially explain the migration and dendritic orientation abnormalities we have observed.
Otherwise, a study has recently described spindle orientation abnormalities similar to Lis1 mutants in radial glial cells of Dcx knock-out mice, which, in turn, lead to moderate proliferation defects [ 135], suggesting that Dcx may play a critical role in neurogenesis through unknown mechanisms.
Similar(57)
"Cognitive impairment" included abnormalities of orientation, memory, or reasoning.
Similar to patterning and shape abnormalities, bundle orientation defects were concentrated, but not restricted to the medial coil (Fig. 5B B″).
These results demonstrated that the loss of primary cilia did not stimulate cell proliferation, but rather caused abnormalities in the orientation of cell division due to abnormal planar cell polarity (PCP) [ 42].
However, these properly positioned neurons exhibited abnormalities of dendritic orientation (see Figure 5).
For example, although dendritic arbors form, abnormalities in dendritic orientation were striking in Gsk3-deleted neurons.
Multiple neurons with obvious abnormalities in dendritic orientation were observed in the upper layers of the cortex (orange arrows).
Furthermore, like ftΔD, Fbxl7 mutations do not display overt abnormalities of hair orientation in the wing, or abdomen (not shown).
FAI describes abnormalities in the orientation of the acetabulum (pincer impingement) or abnormalities in the shape of the femoral head and neck (cam impingement).
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