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Tanaka and colleagues find that aurora B regulates end-on versus lateral kinetochore microtubule attachments differently to ensure that chromosomes orient correctly for segregation in mitosis.
From a grand total of 5 μs of implicit solvent replica-exchange molecular dynamics, we conclude that under folding conditions segments 1 and 4 form more helical structure and orient correctly relative to the native structure more often than do segments 2 and 3. Helices 1 and 2 retain the most residual structure and orientation at high temperatures.
This was confirmed by experiments with magnets: the pigeons could not orient correctly on an overcast day when the magnetic field was disrupted.
The SBDS proinvolved in RNA metabolism and ribosome-associated functions, but SBDS mutation is primarily linked to a defect in polymorphonuclear leukocytes unable to orient correctly in a spatial gradient of chemoattractants.
In order to validate the anchoring of the RH groups to a particular linkage group and to orient correctly the groups on the corresponding chromosome, physical mapping was performed by fluorescent in situ hybridization (FISH) using as probes at least two BACs per linkage group/chromosome.
9 Although SBDS links to RNA metabolism are apparent, an association has also been observed between the SBDS protein and cell locomotion, in that polymorphonuclear leukocytes isolated from SBDS patients are unable to orient correctly in a spatial gradient of chemoattractants.
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We observed that sister chromatids in spc105 cells did not bi-orient correctly on the mitotic spindle; ∼25% remained mono-oriented after 3h at 37° as compared to 0% at permissive temperature (Fig. 3B).
They must also be oriented correctly.
It is very important that the transcript is legible and oriented correctly.
Be sure that if you are using the white spot as a feature to identify the tick that the scutum is clearly visible so that you have the tick oriented correctly and are viewing the dorsal or back of the tick.
Maybe I'm crazy, but if I pull a device from my pocket I don't want to flip it around so the screen is oriented correctly.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com