Eventually, this will enable simulation of 4-dimensional patterns of uterine cellular excitability and organ contraction: a virtual physiological uterus.
This gap in our understanding is important because organ and tissue function are ultimately executed by the specialized behaviors of individual cells (e.g., polarized secretion in excretory organs, coordinated contraction in muscle cells).
After organ culture the contraction curve mediated by ETB receptor was shifted towards the left with an increased Emax of 88±6%6%.
However, these myofibroblasts can severely impair organ function when contraction and extracellular matrix secretion become excessive [29].
In each organ, waves of contraction come in bursts, separated by longer quiescent periods.
To register isotonic contractions, organs were suspended by cotton yarn in organ baths (5 mL) and recorded on smoked drum through levers coupled to kymographs (DTF, Brazil).
The skin brain thesis (SBT) provides a general outline how early nervous systems could have evolved as organs that coordinate contraction-based motility (Keijzer et al. 2013).
The heart is a highly energy-consuming organ, and cardiac contraction is linearly related to mitochondrial respiration thus anthracycline-mediated cardiolipin alterations would be a determinant factor in mitochondrial alterations and cardiotoxicity [ 5, 37, 44, 60].
To register isometric contractions, organs were suspended in steel rods in organ baths (6 mL), connected to a force transducer (TIM 05), attached to an amplifier (AECAD04F) and connected to an A/D converter into a PC running AQCAD® software (São Paulo, Brazil).
Third, although fracturing can clearly be avoided, careful investigation is still needed to determine if thermal contraction of organs might be damaging to them independently of fracturing and conventional chilling injury, a question that to date has not been addressed at all.
