That is, we show that a network motif should not be merely considered as an interaction pattern but be considered as an essential function unit in organizing modules of networks.
Similar to a previous research work on the role of network motifs in information processing [24], we focus on their important roles in acting as functional units in organizing modules.
At the level of network motifs instead of individual proteins, we found two types of hubs, motif party hubs (mPHs) and motif date hubs (mDHs), whose network motifs display distinct characteristics in organizing modules, cellular localizations, controlling network architecture, and co-expression in microarray data.
Recently, by virtue of network motifs, Jin et al. further presented the concepts of 'motif party hubs' and 'motif date hubs', and showed that a network motif should be considered as an essential function unit in organizing modules of biological networks [ 23].
Proteins in living cells are hypothesized to function as parts of a hierarchy of organized modules controlled by biological processes or pathways.
Two key issues under debate are whether natural systems can be interpreted as hierarchically organized modules, and conversely, to what extent synthetic biologists can learn from the interconnection architecture of natural systems (Table 1).
(2) A set of modules that are organized in module libraries, represents the geo-scientific methods.
Both theoretical and numerical analysis show that network motifs should not be merely considered as a connection pattern from topological structures but be considered as essential function units in organizing the modules from biological processes[24].
We must recognize this fact as an emergency call to organize BLS module courses for all university students in the first year of study.
We have used the proposed strategy to organize the module of Parallel Computers and Architectures of the Master's in High-Performance Computing, at the Universitat Aut'onoma de Barcelona, obtaining very promising results.
An interesting observation in the sequence of pPDL2 is the existence of an uniquely organized integrase module (nucleotide position 26697 to 30249).
