A bigger proportion of myocytes in the left atrium had organized T-tubules and topography than in the right atrium.
Similar to control, in HF we also observed 3 groups of cardiomyocytes, although cells with organized T-tubules were found exclusively in the LA.
Organization of the atrial T-tubular network correlates with cell width: cells showing organized T-tubular networks were larger than cells with disorganized or absent T-tubules.
The majority of atrial myocytes with organized T-tubules were isolated from the LA (≈40% versus 2% in LA versus RA).
Caveolin-3 (Cav3)–rich signaling microdomains are found to harbor specific LTCCs that may play an important role in modulation of Ca2+ signaling, particularly in cells lacking organized T-tubules such as atrial and neonatal myocytes.
Although the LA myocardium predominantly consisted of cardiomyocytes with T-tubules, in the RA, we observed 3 groups of cardiomyocytes: cells (1) with organized T-tubules, (2) with disorganized T-tubules, and (3) with absent T-tubules.
Atrial myocytes with organized T-tubules showed a smaller, but still distinct peak in the Fourier transform plot (3.1±0.6 AU versus 11.3±0.9 AU in atrial (n=31 cells from 4 rats) versus ventricular myocytes (n=45 cells from 3 rats), P<0.001).
These findings support the idea that the retarded dissipation of unitary nonjunctional focal Ca2+releases may facilitate the activation of neighboring release sites, leading to recruitment of a larger number of unitary that which in turn improves synchronicity of the atrial [Ca2+] i transients despite their less organized T-tubule network.
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These secondary lymphoid organs are organized in both T and B cell zones.
