Already during the spreading process, aggregates formed, leading to a coexistence of randomly organized domains, consisting of preferentially oriented fibers, embedded in a less ordered matrix of lower density.
They may also form organized domains such as nuclear speckles, P-bodies or stress granules that are visible under the microscope when using specific markers [23], [24], [25].
Reese suggests they provide the scaffolding that allows for "the development of deep hierarchical, highly organized, domain-specific declarative knowledge" (2010, p. 146, and references therein).
Needless to say, these structures and organized domains are established and maintained through non-equilibrium processes.
Schoo et al. (Australia) and Cameron et al. (Canada, doctors only model) presented detailed elements of retention within organized domains [ 35, 36].
Circular ruffles circumscribe relatively large regions of plasma membrane – much larger than other known spatially organized domains for receptor signaling, such as lipid rafts (Prior et al., 2003) or signaling complexes (Kholodenko et al., 2010).
The RCS reference model architecture and methodology provide a simple and systematic mechanism to obtain, describe, and organize domain operational knowledge.
These new methodologies must facilitate the development of know-how and cognitive ability to organize domain knowledge within a holistic mental model allowing for accurate perception of the significance of circumstances and the possible consequences of actions.
