Through different technologically innovative bio-molecular approaches, studies unequivocally demonstrated the cellular heterogeneity of tumors, composed of different set of cells (e.g., differentiated cancer cells, cancer stem cells, non-cancer stem cells and non cancer cells), hierarchically organized and characterized by specific biomolecular and morphological profiles.
The chronic care model (CCM) is a conceptual framework used to organize and characterize these components of comprehensive care for chronic illnesses, which consists of six domains: health system organizations, delivery system redesign, decision support, clinical information systems, self-management support, and community resources and linkages [ 5, 6].
The basic theorem of information theory rests, first, upon the assumption that the message transmitted is well organized, consistent, and characterized by relatively low and determinable degrees of entropy and redundancy.
Results provided evidence of the different processes during the forum and wiki activities: processes such as inferencing, evaluating, organizing and supporting characterized forum discussions while wikis induced mainly processes of producing and developing.
The respective programs are schoolbased or otherwise institutionalized and characterized by organized and purposeful learning activities outside of the family with an intentional education component.
Cell walls of so-called "wood-materials" are constituted by a complex, highly anisotropic and hierarchically organized nanocomposite, characterized by stiff crystalline cellulose nano-fibers, parallel to each other, and embedded in a softer and less anisotropic matrix of hemicelluloses, lignin and water.
The new vessels are different from the angiogenesis in tumors which leads to the formation of a poorly organized vasculature characterized by tortuous and leaky vessels unable to support efficient blood flow (Further investigation will carried out to clarify this point).
We describe the complexity of proteins, expressed through their hierarchically organized energy landscape, and characterize how fluctuations in the hydration shell and the bulk environment influence protein motions and functions.
Most of the systematized scientific activity on hormesis, organized to rationalize and characterize the topic per se, has been done by the University of Massachusetts-Amherst (UMass-Amherst) hormesis program led by Edward J. Calabrese.
Classic LIS (agyria pachygyria spectrum) is typically characterized by a loosely organized and markedly thickened four-layer cortex (compared with the normal six-layered cortical architecture) and apparently normal cerebellum, although some patients have mild vermis hypoplasia (4).
Histological analysis revealed well-defined tissues (intima, media, and adventitia) and a complex and naturally organized ECM, although single components were not quantified and characterized.
