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Later in evolution, the genes may also have helped organize tissues along the axis into discrete and ever more complex body regions.
Active and passive mechanical cell properties, cell cell adhesion, signaling, and genetic control are the principal factors acting in a coordinated manner in order to organize tissues from simple embryonic cell clusters to filigree structures and well organized tissues.
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With colleagues at Harvard and M.I.T., Ingber demonstrated how to precisely organize tissue cells on gold wafers using a stamping tool common on microchip assembly lines.
Based on the central principle of 'adaptive self-organization,' it explains how the interactions of many cells, and of the tiny molecular machines that run them, can organize tissue structures vastly larger than themselves, correcting errors as they go along and creating new layers of complexity where there were none before.
Embryogeny is the pre-natal part of that developmental process where a fertilized egg cell undergoes multiple divisions until an organism with spatially and functionally organized tissues and organs is created.
The epithelial cells of multicellular organisms form highly organized tissues specialized for the tasks of protection, secretion, and absorption, all of which require tight regulation of the core processes of cell polarity and tissue architecture.
To form and maintain organized tissues, multicellular organisms orient their mitotic spindles relative to neighboring cells.
During embryonic development the integration of numerous synergistic signaling pathways turns a single cell into a multicellular organism with specialized cell types and highly structured, organized tissues.
During organ formation, cells proliferate, migrate, and invade into adjacent tissues to produce highly organized tissues, and these same cellular processes are used during carcinogenesis, which results in the formation of relatively organized populations of abnormal cells, which comprise tumors.
Connective tissue is a mesenchyme that fastens together other more highly organized tissues.
Constructing oriented porous architecture in the scaffolds offers the basis for mimicking the structure of highly organized tissues.
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