Tendon formation and repair rely on specific combinations of transcription factors, growth factors, and mechanical parameters that regulate the production and spatial organization of type I collagen.
We suggest that the presence (and perhaps better organization) of type II collagen fibers and chondrocytes seen on histology results in greater strength.
Similar to what was observed in Prox1flox/flox Tg(Pax2-Cre) P1ps, P1 Prox1flox/flox;Tg(Nes-Cre) mice showed severe disruption in the organization of Type II fibers (Fig. 9A,C,D,H).
The genetic organization of Type III was similar to Type II but, in addition, it contained a 1200 bp sequence insertion located upstream the promoter of the relBE2Spn operon.
Therefore, although macromolecular organization of type X collagen has not been reported in vivo, the ECM structure found in the presumptive bone-implant interface may indeed contain type X collagen.
Also, fibronectin is associated with melanoma progression (Gaggioli et al., 2005) and can regulate the organization of type I collagen fibrils (Sottile and Hocking, 2002).
The presence of higher levels of type III collagen may have beneficial effects on early wound healing process and result in better organization of type I collagen in the final scar [ 32].
Figure 6 Systemic organization of types of 'explaining' — three steps in delicacy.
"Of course you can't rule out at the moment that terrorist organizations of this type have coalitions, reach agreements, help each other," he said when asked a question about possible ETA links with radicals in Iraq.
Some analysts said Aetna's troubles portended the demise of stringently controlled health maintenance organizations of the type that Mr. Huber bought from U.S. Healthcare in 1996 to begin Aetna's transformation.
