USP4, USP11, and USP15 are paralogous DUBs as evidenced by structural organization and sequence similarity.
Since FERM domain proteins control cytoskeletal functions in differentiating cells, and the human EHM2 gene has not been characterized, we investigated EHM2 steroid-regulation, genomic organization, and sequence conservation.
The scope of the rule of Baker v. Selden is an issue in the current controversy over whether copyright protection for computer software extends to the visual "desktop" on which the computer operator views "icons" representing documents, files, programs, and so on, and to the organization and sequence by which the operator is led through a program.
In Asian isolates, the TRI1 TRI16 locus, which determines type A versus type B trichothecene production in other species, is more similar in organization and sequence to the TRI1 TRI16 locus in F. sporotrichioides and F. langsethiae than to that in F. poae.
On the basis of virus structure, genome organization and sequence relatedness, the family Paramyxoviridae is divided in to two subfamilies: Paramyxovirinae and Pneumovirinae [1].
The non-structural genes are composed of the integrase followed by polymerase, repressor, anti-repressor and the primase, resembling in organization and sequence the APSE-1 phage that infects Acyrthosiphon pisum [19].
A survey of CH34-related genomes using the MaGe interface reveals that the C. pinatubonensis JMP134 megaplasmid displays an acxRABC operon almost identical to the CH34 acx locus in organization and sequence (Ceut_C6170/72/73/74; with aa sequence identities of 89-93% between the respective ACX subunits and 71% identity between the AcxR proteins).
It is interesting to note that the DNA-packaging and head genes resemble in organization and sequence the lambda-like phages, and the baseplate, tail, and tail fibers genes (gpV, gpW, gpJ, gpI, gpU, gpX and gpD) resemble the P2-like phages.
Most of the paramyxoviruses that are isolated from avian hosts are classified in genus Avulavirus of subfamily Paramyxovirinae: the only exceptions are the avian metapneumoviruses, which are classified in genus Metapneumovirus of subfamily Pneumovirinae due to substantial differences in genome organization and sequence relatedness [1].
Gene organization and sequence conservation was particularly evident among paralog groupings and within salmonid subfamilies.
