The neuroligin 3 gene (NLGN3) and neuroligin 4X gene (NLGN4X), localized on Xq13.1 and Xp22.33, encode a member of a family of neuronal cell surface proteins serving as splice site specific ligands for neurexins and may be involved in the formation, organization and remodeling of central nervous system synapses.
These considerations justify the search for more effective interventions, which rely on better understanding of the pathogenesis of pleural organization and remodeling [8].
These efforts have been impeded by the lack of a survivable murine model that reliably allows investigation of the pathogenesis of pleural organization and remodeling.
We found that PGE2 can contribute to organization and remodeling of the visceral pleura after S. pneumoniae induced injury in part by promoting MesoMT in an EP3-specific manner.
The down-modulated genes in IE valves mainly belong to structural organization or remodeling (n = 9), proliferation/death (n = 7), metabolism (n = 7) and miscellaneous (n = 31) functional groups.
Linked to our findings that SAP-EGF accelerates wound reepithelialization, these previous studies suggest that wound coverage with SAPs may enable dermal responses as well, such as the early organization and remodeling of the provisional wound matrix.
A deregulated apoptotic process, which leads to defective structural organization and remodeling in mammary gland, is believed to be directly related to breast cancer etiology [ 41, 42].
Perhaps the fragmentation process is a side-reaction where the fission promoting machinery may have a secondary role in lipid organization, cristae remodeling and/or pore assembly 59– 61.
They are required for cell attachment, tissue organization and remodeling, and for the differentiation of chondrocytes to produce mineralized bones (Gelse et al., 2003; Wilson et al., 2011).
A dominant effect of TSA treatment is the regulation of chromatin organization and remodeling genes, which are significantly enriched (p-value <10-6).
