Documenting the extent of cellular diversity is a critical step in defining the functional organization of tissues and organs.
Macrophages are involved in ECM remodeling, proliferation of epithelial cells, development of vasculature and the organization of tissues during development [65].
Targeted molecular imaging to detect changes in the structural and functional organization of tissues, at the molecular level, is a promising approach for effective and early diagnosis of diseases.
MRI with diffusion tensor imaging (DTI) characterizes the diffusion of water molecules in tissue environments, which is influenced by the microstructural organization of tissues and their constituent cells, and can provide unique insights into pathophysiology, particularly in white matter.
From another point of view, several works in the last decades have paid attention to the establishment of polarity and organization of tissues in the developing embryo and apical meristems and differentiation of primary vascular tissues focusing on the balance and hormonal signals that determine these processes (f.i. [ 32- 34]).
There were ten genes with increased expression (Esm1, Okl38, Mustn1, Omd, Spp1, Serpine1, Rnf39, Mafk, Gpnmb, Dyrk1a) and seven genes with reduced expression (Col3a1, Pvalb, Acsl6, Ret, Cxcl12, Rtn4, Ddah1) related to morphogenesis, organogenesis and organ development, a group involved in the formation and organization of tissue and organ structure.
Using cell-graphs, the structural organization of tissue samples are captured.
Diabetes Care 2013 36:701–707 The organization of tissue in key areas of the brain may be related to bloating, gastroparesis, and other symptoms that are common among people with diabetic autonomic neuropathy.
Nonetheless, these results, together with the analysis of rosette formation and cell movement at early stages, suggest that rosette formation not only mediates cell internalization, but also contributes to the organization of tissue movements in the surface layer, including those that generate superficial bilateral symmetry.
One of the most challenging problems in biology resides in unraveling the molecular mechanisms, hardwired in the genome, that define and regulate the multiscale tridimensional organization of organs, tissues and individual cells.
A heterogeneous population of differentiated cells from hESCs may lead to inferior tissue function and organization of engineered tissues [16], [17].
