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Molecular tethers have a central role in the organization of the complex membrane architecture of eukaryotic cells.
The hierarchy of relative stabilities given by the EDMs sheds a new light on the EF-CaM interaction mechanism described experimentally and supports an organization of the complex architecture centered around nucleation points.
Subsequent mapping of the site of the cross-link by peptide mapping provides important information concerning the organization of the complex and the trajectory of the nucleic acid components over the surface of the protein.
However, the brain networks have also been shown to be highly modularized [30], [38], [40], [43], and thus raises the question as to whether the global network quantities are informative enough to depict the local topological organization of the complex brain networks.
The model reveals roles of individual subunits in the organization of the complex.
The EM map was divided into segments to reflect the modular organization of the complex.
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Data indicate a virus-like organization of the complexes, in which a DNA core is surrounded by a solvent-exposed protein layer.
The organization of the complexes in the membranes is different from any previously observed: with areas of crystalline core-complexes, crystalline peripheral antennae, mixed domains, and apparently pure lipid membranes devoid of protein.
The liquid state model that envisions respiratory chain complexes diffusing freely in the membrane is increasingly challenged by reports of supramolecular organization of the complexes in the mitochondrial inner membrane.
Both the composition and the spatial organization of the multilayered complex mixtures are probed.
This leads to a model for the higher organization of the Atg1 complex in PAS scaffolding.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com