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Here, we review recent studies showing that this complexity can be understood in terms of the supramolecular organization of proteins, which self-assemble within a hierarchy of different length scales, including complexes, supercomplexes and nanodomains.
So I went to work with Chothia at the Medical Research Council Laboratory of Molecular Biology in Cambridge, exploring protein families and the domain organization of proteins in the first completely sequenced genomes.
So I went to work with Chothia at the Medical Research Council Laboratory of Molecular Biology (MRC-LMB) in Cambridge, exploring protein families and the domain organization of proteins in the first completely sequenced genomes.
This is consistent with the high degree of organization of proteins comprising the postsynaptic density.
There has been renewed interest in understanding the structural and architectural organization of proteins through a network representation of proteins.
The organization of proteins involved in the formation of focal adhesion complexes provides an opportunity to learn more about the effectiveness of cell-to-substrate interactions.
Similar(31)
Spatiotemporal organization of protein interactions in cell signaling is a fundamental process that drives cellular functions.
SAXS can efficiently reveal the spatial organization of protein domains, including domains missing from or disordered in known crystal structures, and establish cofactor or substrate-induced conformational changes.
The organization of protein structures in protein genotype space is well studied.
The organization of protein structures in sequence space has several general features.
This observation underscores the importance of studying the organization of protein functions in sequence space independently from the organization of structures.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com