Sentence examples for organization of enzyme from inspiring English sources
From the point of view of protein stability the organization of enzyme active sites is inherently unstable because these sites are optimized for catalysis, which means they are pre-organized to stabilize the transition state(s), rather than the protein [15], [16].
In our study, we expanded this line of research to include comparisons of the underlying respective network topologies as well as to investigate whether the spatial organization of enzyme interactions correlates with metabolic efficiency.
In addition, potential interaction between ATP sulfurylase and APR reductase as a protein complex in onion suggests additional organization of enzyme activities in the plant sulfur assimilation pathway [ 29].
The cooperative organization of enzymes by cells is a key feature for the efficiency of living systems.
A key characteristic of these highly efficient enzyme pathways is the cooperative and spatial organization of enzymes to ensure the sequential conversion of substrates (Fontes and Gilbert 2010; Park et al. 2014).
The effect of this systematic organization of enzymes is very distinct, in that it enhances the overall efficiency of molecular activities by increasing the local enzyme substrate concentrations and channeling intermediates between consecutive enzymes to avoid competition with other reactions present in the cell (Park et al. 2014).
Our main goal is to understand the cause for the emergence of this global supramolecular dynamic organization of enzymes.
A strategy that mimics this organization of enzymes would facilitate the design of efficient metabolic pathways.
To gain further insight, we studied the physical organization of enzymes carrying high fluxes in greater detail.
Bioinformatics methods that facilitate the organization of enzymes into superfamilies based on common tertiary structure and a fully or partially shared mechanism have also emerged.
Conversely, the biochemical reactions that underlie metabolic functions in cells are well understood [ 4], and have been reproduced in vitro [ 5, 6]; nevertheless, aside from a few exceptions where enzymes form macromolecular complexes [ 7- 9], little is known about the cellular organization of enzymes.
