Genes belonging to these modules were related to processes such as the regulation of cytoskeleton organization, growth (Module E), biological adhesion (Module F), anatomical structure morphogenesis, and cell junction organization (Module G; Table 1).
The curricular aspect/website function scale comments were categorized as no meaningful response, overall quality of the module, factual content of module, content organization, module images, module length, question quality, question quantity, or website function.
To facilitate discussion, representative names were assigned to each module based on GO terms: Module 1, heme biosynthesis; Module 2, respiration and energy generation; Module 3, cell wall organization; Module 4, cell cycle; Module 5, transport; Module 6, pyridoxine biosynthesis; Module 7, RNA processing; and Module 8, undefined function, because no GO term enrichment was found.
The organization into modules and the content of each module were decided using a participative process, after an inventory of training programmes in population and health in several francophone African countries [ 13].
This procedure automatically constructed a hierarchical organization of modules in both: in the ESP map it identified 113 modules covering 264 genes (out of 424) and in the CB map it identified 242 modules covering 487 genes (out of 743).
Understanding the organization of modules and their structural and functional roles emerges as a new challenge when studying biological networks.
Hierarchical organization of modules has been observed for metabolic and transcriptional networks of E. coli [ 70- 72] and metabolic networks of 42 other organisms [ 73, 74].
Each facet depicts a higher-order organization of modules of G. Recall that inter-facet functional orthogonality demands that each of the n facets is based on an orthogonal functional concept facets that are distinctive and functionally apart from each other.
Module groups in overlap plot also suggest the hierarchical organization of module where genes are grouped into modules that are clustered into supermodules [ 18].
We found that the global modular organization and module membership of ROIs were unchanged with local changes especially in the basal ganglia.
