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Several studies have identified key roles for lipins and their regulators in nuclear envelope organization, gene expression and the maintenance of lipid homeostasis in yeast and metazoans.
They may serve as decoys, sponges, signals or scaffolds in regulating chromatin conformation, nuclear organization, gene expression, and protein activity in cis or trans manner (Ulitsky and Bartel, 2013; Quinn and Chang, 2016).
Here we discuss the definition of LAPs, review their many binding partners, elaborate their functions in nuclear architecture, chromatin organization, gene expression and signaling, and describe what is currently known about their links to human disease.
Utilizing a micro-photopatterning (μPP) model system to precisely arrange cell-adhesive patterns, we examined the effects of substrate architecture at these length scales on human mesenchymal stem cell (hMSC) organization, gene expression, and fibrillar collagen deposition.
Aurora B and MSK1 are thought to be involved in chromatin organization, gene expression, and carcinogenesis [ 14, 15].
In eukaryotes, epigenetic DNA methylation plays roles in chromatin organization, gene expression, and genome maintenance, and its disturbance is related to human diseases.
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Integrin binding transmits signals into the cell that result in cytoskeletal re-organization, gene expression and cell differentiation.
In order to determine whether this organization named isochore organization influences gene expression patterns, the relationship between GC content and gene expression has been investigated in man and mouse.
To examine epigenetic influences on the large-scale organization of gene expression levels, we studied the relationship of gene expression organization in the hippocampus with stable individual differences in activity in the open field in genetically identical mice.
Here we discuss studies designed to probe the causal impact of genome organization on gene expression.
The influence of RGD-coupling on the orientation, proliferation, ECM organization, and gene expression of hCFs was assessed.
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CEO of Professional Science Editing for Scientists @ prosciediting.com