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The skull, however, was flatter and more elongated that's the feature that has changed most since our days in Irhoud, likely in response to a series of genetic mutations that are known to have improved our brain organization, connectivity, and development.
Notably, the present findings confirm three out of four complementary criteria for the definition of cortical areas that have traditionally been advocated (Van Essen, 1985), namely topographic organization, connectivity and functional properties (the fourth one being cyto- and myeloarchitectonic organization).
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It is already discovering new genetic loci and even entire genetic networks that affect brain organization and connectivity.
Several lines of evidence implicate changes in synaptic organization and connectivity.
While traditionally quite distinct, functional neuroimaging (e.g. functional magnetic resonance imaging: fMRI) and functional interference techniques (e.g. transcranial magnetic stimulation: TMS) increasingly address similar questions of functional brain organization, including connectivity, interactions, and causality in the brain.
We then used this approach to investigate retinotopic organization functional connectivity in multiple levels and analyses.
Abnormalities in structure, organization, and connectivity of the brain are all indicators of irregular neural cell migration and proliferation.
28 It is thus possible that the selective vulnerability of hippocampal regions in these two conditions may be related to their anatomical organization and connectivity patterns.
Thus, to date, using fMRI, the literature investigating the effect of age of seizure onset on brain functional organization and connectivity in TLE is particularly sparse.
Unfortunately, these studies could not address the topographic organization of connectivity within the EC, possibly due to limitations in resolution and SNR.
33 This approach consists of removing all of their visual input and examining the effect of this loss on the functional organization and connectivity of their neocortex.
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