Sentence examples for organization alterations from inspiring English sources

The polyps in patients hemizygous for a defective APC (disrupting the wnt/wingless pathway) and the dysplasias preceding neoplasia both in retinoblastoma and in the lethal giant larva mutant in Drosophila that eventually result in neuroblastomas are tissue organization alterations in which the underlying cause may be altered morphogen/morphostat gradients [ 1].

Finally, we observe that the cells lacking ORCA display abnormal heterochromatin organization and alteration in the replication timing, specifically at the late-replicating regions.

Interactions with these fibrils lead to membrane deformation, the local impairment of ER organization, and profound alterations in ER membrane dynamics at the inclusion periphery.

Impaired cell organization and cytoskeletal alterations lead to morphological changes such as an increased cell volume and cell surface [ 4].

Under certain circumstances, the SD2 domain is both necessary and sufficient to induce changes in cytoskeletal organization and subsequent alterations in cell morphology (Hildebrand and Soriano, 1999; Hildebrand, 2005).

From this perspective, it is reasonable to hypothesize that extemporaneous exposure to estrogens or xenoestrogens during fetal development may alter the reciprocal interactions that induce and maintain tissue organization, and that these alterations in turn generate abnormal tissue structures and altered control of cell proliferation.

Thus, the Y27632-induced bending and altered dynamics of filopodia are probably due to alterations in organization of the core actin bundle of each filopodium and to the expected alteration in cell-body contractility caused by reductions in contractile stress fibers.

The relationship between three-dimensional chromosome organization and gene expression alterations underlying disease progression warrants further investigations.

What are the consequences of disrupting this organization, and do such alterations underlie diseases?

Such changes in nuclear organization may also entail alterations in the epigenetic make up during cell senescence or vice versa.

We suggest that alterations in organization of β-actin resulted from a decrease of its arginylation could be responsible for the observed effects of arginine deprivation on cell invasiveness and migration.