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On the other hand, the organization of the cytoskeleton affects cellular organization, adhesion complexes and polarity, and vesicular transports.
Ras homolog gene family, member A is a critical signaling molecule regulating a variety of cellular processes, such as cytoskeletal organization, adhesion, and apoptosis.
Particularly, it plays a key role in cell surface structure organization, adhesion and migration, and it has been implicated in various human cancers [ 44, 45].
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Seventeen out of 20 of the most overrepresented GO terms for this set of genes were specifically related to muscle and the other three were actomyosin structure organization, cell adhesion, and biological adhesion (DAVID functional analysis tool).
Activation of the EGF pathway alters components of the cytoskeleton involved with actin organization, focal adhesion formation and resolution, as well as cell-cell adhesion [ 49].
Fig. 2 NRVM viability, organization, and adhesion rate on collagen and CNH-Col substrates.
This study examined ECM production, cytoskeletal organization, and adhesion of primary human osteoblastic cells on biodegradable matrices applicable for tissue engineering, namely polylactic-co-glycolic acid 50 50 (PLAGA) and polylactic acid (PLA).
Therefore, the RhoA/ROCK signaling pathway is proposed to play a pivotal role in diverse cellular functions, including expression and activity of endothelial nitric oxide synthase, vascular smooth muscle contraction, actin cytoskeleton organization, cell adhesion and motility, proliferation, and hypertrophy in smooth muscle cells (Noma et al. 2006 Somlyo and Somlyo 2003 Gerthoffer 2003 Gerthoffer
"Non-epithelial" kinase genes were associated with cytoskeleton organization, cell adhesion, mesodermal and epidermal development.
Our data indicate that cytosolic SYT functions to modulate cytoskeletal organization and adhesion in response to specific matrix substrata.
Recent work has shown alteration in the normal human prostate tissue organization and adhesion molecules during prostate tumor progression[5], [15].
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