We observed striking abnormalities in the organization of interphase microtubule arrays (Fig. 2D).
Bisbenzamide staining of nuclear DNA was performed to ascertain whether there were any gross morphological abnormalities in retinal organization.
Because APP derived polypeptides are significantly changed in APPYG/YG mice, we analyzed whether these mutant mice show abnormalities in brain organization.
Altered morphology was associated with defects in actin that was concentrated at the cell periphery and with abnormalities in microtubule organization.
Mafb CE cochleae show no gross abnormalities in neurite organization.
Abnormalities in chromatin organization have been described in a variety of diseases [ 1, 2].
Perlecan knockout mice are not viable, resulting in early neonatal death due to abnormalities in ECM organization [ 54].
Thus, R552H heterozygotes do not display major abnormalities in synaptic organization or transmission in the dorsolateral striatum.
The absence of CL results in structural abnormalities in the organization of complexes that have direct functional consequences.
Abnormalities in structure, organization, and connectivity of the brain are all indicators of irregular neural cell migration and proliferation.
