Parvizi et al. (2008a) reported on "the changing organism profile in periprosthetic infection", which is another risk factor not recorded in the NAR.
The disparity in organism profiles between studies may reflect regional variation, patterns of antimicrobial use, methodological differences, or disease severity patterns.
Future well-designed (preferably multi-center) prospective pharmacokinetic and –dynamic studies should evaluate the association between dosing schedules, micro-organism profiles and therapy efficacy, preferably including long term patient outcome.
These methods assume that all miRNAs present in the organism are being profiled in the experiment.
As for model organisms, the profile of the sperm surface glycans could serve as a valuable resource for related biological studies.
The assembled RNA contigs can then be used to predict the organisms functional profile directly, using the same techniques as in the genome-based approach.
Although the sequence homology of Rif1 is poor between unicellular and multicellular organisms, the profile based search strongly supports the conservation of this DNA binding domain between these two groups of organisms.
In recent years, development of DNA microarrays has allowed researchers to study the complete genome of an organism and profile transcriptional expression patterns of up to tens of thousands of genes in a single experiment [ 1- 3].
For example, functional links are suggested by conservation of gene neighbourhood and gene order [ 26], gene fusion events [ 27], correlation of the genes' evolutionary rate [ 28] and correlation of genes' occurrence in organisms (phylogenetic profiles).
The change from intravenous to oral therapy is effected as soon as we have a full organism sensitivity profile and after consultation with our infectious diseases team with whom we have a fortnightly multidisciplinary meeting (IV antibiotics for 1 week: four patients, 2 weeks: seven patients, 6 weeks: 17 patients).
