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We envision that CombiGEM could be extended to other model organisms, disease models, and phenotypes, where it could accelerate massively parallel combinatorial genetics studies for a broad range of biomedical and biotechnology applications, including the treatment of antibiotic-resistant infections.
However, the resistance to drugs and pesticides in pathogenic organisms, disease vectors and agricultural pests has generally developed shortly after the introduction of new molecules often resulting in significant control failures [1], [4].
To define term domains, information such as the top 16 categories ("Anatomy", "Organisms", "Disease, Chemicals and Drugs", and so on) of MeSH (Medical Subject Headings) may be helpful.
This observation has important implications for the applicability of so-called signature transcripts to diagnose cellular status (e.g. starvation for a nutrient, stress or, in higher organisms, disease).
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This report indicates that Ranavirus should be considered into the aquatic organism disease etiologies throughout this geographical region.
This process enabled us to identify, for each mammalian model organism, disease classes having evolutionary rates that deviate significantly from the distribution observed for all human disease genes.
Quorum sensing allows bacteria populations to communicate and coordinate group behaviour and commonly is used by pathogens (disease-causing organisms) in disease and infection processes.
disease -- Organisms suffer from disease when their normal function is impaired by some genetic disorder, or more often from the activity of a parasite or other organism living within them.
Because of cross-reactive antigens Borrelia burgdorferi (Bb) shares with other organisms, Lyme disease can be overdiagnosed.
"We are moving organisms and disease and pathogens - all over the planet weeds and other exotic species are proliferating like crazy!" Anyone who has been keeping track of the ash dieback story in recent months would probably agree.
So far, more than 800,000 samples have been analyzed, covering the gene expression in a vast array of organisms and disease states.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com