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Such prior physiological information may range from the organism level (organ volumes, blood flow rate, etc).
The eventual outcome at the organ or organism level may in turn be modulated by the ability of downstream genes and proteins to compensate for these variations.
"We're developing advanced imaging tools from the cellular, to the organ, and up to the whole organism level".
Biological systems are hierarchically organized, from genes to proteins up to the organism level.
The flexible use of glucose and lactate as fuels on the cellular level is mirrored at the organism level.
With the existing technologies we are able to investigate subproteomes at the organism level, ignoring the differences between individuals.
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Agent-Based Models (ABMs) have previously been used to simulate inflammation at various scales up to the whole-organism level.
Thus hypoxia and anoxia are useful tools for eliciting information on respiratory control mechanisms at the whole-organism level of integration (e.g. [13] [17]).
Thus, we demonstrated the importance of AMPK in the circadian rhythms of behavior, energy metabolism and gene expression at the whole-organism level.
Thus, atherosclerosis results from the complex interplay of genetic and environmental risk factors at a whole-organism level (Fig 1).
We observed significant gene expression changes between the T4 treatments at Day 2, prior to observable morphological changes at the whole-organism level.
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