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Experimental models in use for the study of the ischemic heart involve studies on the integrated organism, experiments with isolated hearts or multicellular preparation, and also studies of cells isolated from the heart.
The crustacean Daphnia magna was used in all whole organism experiments.
> -wrap-foot> Altheugh thexperimentalassaysays depicted in Table 4 are most often carried out by transfecting expression and reporter plasmids into cell line model systems, transcription regulation annotations can also be supported by whole organism experiments, e.g. knock out mutations or RNAi knock down strategies.
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For experimental data of follow-up experiments, the application provides a flexible query mechanism which accepts organism, experiment classification and experiment type as parameters.
Finally, well-informed and designed whole-organism experiments (e.g., rodent bioassays) will still be necessary because they better capture the relevant exposure(s) and dose responses in bioactivation, detoxification, mutagenesis, genome maintenance/dysregulation, and ultimately cancer.
While in vivo animal models are necessary to show that a phenomenon occurs in living organisms, experiments in live animals typically involve undefined and uncontrollable factors [ 43].
Another frequent task is the visual comparison of different data sets that are related to different physiological conditions, different organisms, experiments versus simulations or dynamic system states at different times.
A variation cannot be identified as genotypic by observation of the organism; breeding experiments must be performed under controlled environmental conditions to determine whether or not the alteration is inheritable.
This is due to the different number of organism specific experiments and the evolutionary distance between the species and the reference species.
In order to more fully characterize the importance of specific macrophage effector mechanisms against this organism, however, experiments utilizing primary macrophages derived from a variety of wild-type and transgenic mice will need to be conducted.
For example, the Stanford Microarray Database [ 5] supports browsing based around organisms and experiments, and more complex Boolean searches based on criteria such as experimenter, organism and category of experiment.
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CEO of Professional Science Editing for Scientists @ prosciediting.com