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The assessment of toxicity at the levels of whole organism, cell, and gene is one way by which researchers are able to determine how much of a toxin an organism can be exposed to before adverse effects set in.
The exact history of cell divisions that an organism underwent since its beginning is naturally represented by a mathematical tree, which we call the organism cell lineage tree ([1], Figure 1A).
The age of large-scale high-throughput data generation in biology started with the introduction of microarrays that could be used to measure a large portion of the transcriptome of an organism, cell type, or tissue in parallel.
For a normal mammalian organism, cell division coordinates with overall growth controlled via extra-cellular signals.
Organism, cell type, experiment timing and other conditions are crucial for determining whether an edge exists in a signaling network.
Apoptosis (programmed cell death I) is a tightly regulated pathway, which is involved in organism cell death [ 10– 10].
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In a multicellular organism, cells become specialized to perform different functions through the process of differentiation.
In a multicellular organism, cells contain the same genes.
Pathway choice depends on the organism, cell-cycle phase, and cellular context of the lesion (Shrivastav et al. 2008).
Each reaction is linked directly to the published literature and information pertaining to the host organism, cell-type and subcellular location.
In the organism, cells are predominantly contact-inhibited.
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CEO of Professional Science Editing for Scientists @ prosciediting.com