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The calculated activity in the whole organ was plotted as a function of time to yield the organ time activity curves.
To investigate the effect of the altered sampling schedules on the estimation accuracy of TIACs in PRRT, biokinetic data of each patient were modified in five cases (Table 2; Fig. 1): omitting either one up to four time points for every organ and the corresponding serum measurements (case I IV) or omitting all serum measurements but including all organ time points (case V).
In patients with disease confined to a single organ, time to new metastatic sites was calculated from baseline to the appearance of new metastatic sites.
These three dimensional plots are necessary in order to handle the fact that, in a growing organ, time and space are intimately but non-linearly linked.
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Writing from Beirut for The Times's house organ, Times Talk, he gave credit to his driver, Mohammed Kasrawi: "During the fighting and numerous cease-fires, it was Mohammed who knew on a particular day which streets were safe to cross, which faction controlled which block, where the retaliatory and often murderous kidnapping of civilians was likely to take place".
Fig. 3 Organ time-activity curves based on mono-exponential fittings for all of the patients.
Other organs were delineated semi-automatically to derive organ time-activity curves [11].
Fig. 4 Organ time-activity curves corrected for 68Ga physical decay.
Organ time-activity curves corrected for 68Ga physical decay are shown in Fig. 4.
Organ time-integrated activity coefficients, equivalent to the number of disintegrations per unit radioactivity (MBq-h/MBq), were calculated using the extrapolated values for human organs by integrating the area under the time-activity curves.
Cumulated activities were calculated as areas under the curves of RM and organ time-activity data by using the trapezoidal rule and assuming physical decay after the last measurement.
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