Sentence examples for organ side from inspiring English sources
Though this approach has been encouraging, there have been major challenges with respect to off-target organ side effects and systemic toxicities related to the widespread distribution of these signaling pathways in multiple cell types and tissues.
The console was moved back to the organ side of the transept, with the action going backward under the floor into the organ.
Long-term, continuous Gamitrinib treatment of TRAMP mice was feasible, devoid of systemic or organ side effects, in vivo.
In addition, computational modelling at tissue and organ levels can be helpful in predicting cardiac (and, increasingly, other organ) side effects.
The pharmacological and genetic evidence cited above validate gamma-secretase as a target for lowering Aβ production as well as non-target organ side effects due to inhibition of Notch signaling.
However, inhibition of Notch processing by non-selective GSI's manifests in dysregulated cellular homeostasis and non-target organ side effects, for example, goblet cell hyperplasia in the gastrointestinal tract [ 28- 30], that translate to clinical observations [ 31- 33], and present challenges for clinical development of first generation GSI's [ 34].
Microbrachius fossils that don't sport the grooved bones, presumed to be females, instead have dermal plates beneath the pelvis; ridges and bumps on the inside of those plates probably helped the females firmly hold the males' organ during side-by-side copulation (artist's representation above).
This approach enhances the efficacy of the therapeutic agent with respect to synovial inflammation, while markedly reducing non-target organ adverse side effects.
Treatment with prebiologic agents is limited to rotational therapy due to concerns of cumulative toxicity and major organ adverse side effects; the advent of biologic agents has increased feasibility of continuous therapy for long-term control, particularly in patients with recalcitrant disease.
Future immunosuppressive strategies will have to concentrate further on the omission of organ-damaging side effects.
The envelope bulks up the drug to such a size that it cannot exit the blood stream and enter healthy organs, preventing side effects including liver and heart damage.
