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These experiments revealed an expression pattern supporting the organ classification based on morphological characteristics.
Details of all AEs resulting in drug discontinuation were classified using the MedDRA system organ classification [ 17].
Adverse events were analyzed using MedDRA by system organ classification and the subcategory, preferred term (which represents a single medical concept).
DRGs were merged when they involved patients within the same organ classification undergoing similar surgical procedures with bleeding differences (<3%) (Additional file 2) to increase the power of the statistical analysis.
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Any AE reported post-treatment was considered a Treatment-Emergent Adverse Event (TEAE) and were summarized by treatment group, using a Medical Dictionary for Regulatory Activities (MedDRA) version 13.1 preferred terms, system organ classifications, and severity.
Birth defects were coded using an organ system classification to increase the possibility of detecting a potential signal by grouping together similar defects or defects with similar aetiology.
It is therefore of paramount importance to have a valid and reliable organ dysfunction classification system for both clinical and research purposes.
Therefore, it is of paramount importance to have a valid and reliable organ dysfunction classification system for both clinical and research purposes.
Afessa and coworkers [ 8] also used the Knaus organ failure classification [ 14] and found an independent increased odds of hospital death of 5.5 per organ failure (excluding respiratory organ failure).
Risk factors for recurrent prolapse are poorly understood, but it appears that women aged less than 60 years and women with higher grades of prolapse (International Continence Society pelvic organ prolapse classification [ICS POP-Q] stages 3 and 4) are more likely to experience recurrent prolapse after vaginal repair surgery.
Birth defects were grouped according to an organ system classification: central nervous system, eyes, face (including neck and ears), hepatic/digestive, musculoskeletal (including cranial bone alterations), cardiac, genitourinary, chromosomal, extremities and others [ 23]. "Minor" anomalies are excluded, when isolated, because they have lesser medical, functional or cosmetic consequences.
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