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They tested the idea on members of the Religious Orders Study, whose life experiences were more similar than the general population's.
The Religious Orders Study and Rush Memory and Aging Project have 19 cognitive performance tests in common, and use identical analytic procedures to develop summary statistics.
Participants in the Religious Orders Study were older Cathololic nuns, priests and brothers from about 40 groups in 12 states across the United States.
Allele frequencies were not significantly different between the Religious Orders Study and Rush Memory and Aging Project subjects, supporting the validity of pooled analyses.
Clinical and post-mortem data came from participants in the Religious Orders Study and Rush Memory and Aging Project, two longitudinal, epidemiologic clinical-pathologic studies of aging and AD [17].
Thirty-two sinucleotideotide polymorphisms (SNPs) previously implicated in AD susceptibility were genotyped in 414 subjects with both annual clinical evaluation and completed brain autopsies from the Religious Orders Study and the Rush Memory and Aging Project.
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Each enrolled patient was then assigned the next sequentially ordered study pack.
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