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This is in violation of the biological reality that parents with various orders of regulation can jointly regulate a child.
Our proposed method supports multiple parents to regulate a child simultaneously, with different orders of regulation.
Complications in the alignment of data samples can arise if the parents have different orders of regulation with the child node.
Unlike the approach in basic MIT and other approaches where zero and higher-order interactions are scored separately and then combined, in our approach, we also condition (during computation) on parents which have different orders of regulation with the target gene.
Similar(53)
Recall that r is the maximum order of regulation between the target gene and its regulators.
The FPC has overall responsibility for financial regulation in the UK and is part of a new order of regulation designed to keep the banks under closer scrutiny.
To remedy this situation, we propose to apply the penalization only on a per-order of regulation basis.
These include Standard Pearson correlation technique to measure statistical significance of synchronous co-regulation of genes and order of regulation [ 14].
For the first n columns, the entries marked by 1 correspond to instantaneous regulations whereas for the last n columns non-zero entries denote the order of regulation.
That is, it will take into consideration the d-th order Markov rule, for a gene having a maximum order of regulation d with its parents.
Zou et al. [ 2], while highlighting the existence of both instantaneous and time-delayed interactions among genes while considering the parent-child relationships of a particular order, did not account for the regulatory effects of other parents (having different order of regulation than the current one) on that particular child.
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