Wound healing is an orderly and coordinated tissue repair process mainly consisting of three overlapping phases: inflammation, granulation tissue formation, and tissue remodeling.
We thus propose that predictable, orderly, and durable tissue regeneration should be based on a "developmental RE-engineering" paradigm, with the challenge to instruct the execution of developmental programs in the context of an adult system.
Moreover, by the loss of tight junctions the orderly structure of tissue will no longer be maintained and tumor cells detach more easily from the tumor and invade surrounding tissues [166].
The S-Group displayed an orderly pattern of tissue repair with type II collagen staining positive in the cartilaginous layer down to the interface with the subchondral bone, and type I collagen staining uniformly positive in the subchondral tissue or associated with single cells in the chondral region.
The possibility of a cell-free implant that is 'smart' enough to provide the joint with the appropriate stimuli to induce orderly and durable tissue regeneration is an attractive prospect, and new biomaterials and surgical strategies have been recently proposed to induce in situ cartilage regeneration after direct transplantation onto the defect site.
The neuron-specific molecule is involved in early embryonic events but also mediates neurite fasciculation, neuromuscular interaction, and orderly layering of neural tissue.
Therefore, under normal fetus growth and the low oxygen tension of the placenta, the energy produced and consumed by the growing fetus is sufficient to support the orderly growth of the tissue masses.
The features of orderly growth of fetal tissues resemble many of the lawless growth properties of cancer cells when the balance between tumoricidal (Yin) and tumorigenic (Yang) properties of acute inflammation is lost in favor of cancer cell growth.
Without sufficient oxygen, the orderly processes by which the tissues unfold and the organs develop is disrupted; malformations and other abnormalities then occur.
As previously reported, some scaffolds displayed a potential to act by themselves as stimuli for the differentiation of resident bone marrow stem cells, by inducing an "in situ" tissue regeneration that allows an orderly and durable osteochondral tissue without the need for any cell augmentation (Kon et al. [2012b]; O'Shea and Miao [2008]; Keeney and Pandit [2009]; Lopa and Madry [2014]).
